Butterbur 75 mg, 60 vcaps by NOW

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Product Code: EM-N4602

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Ingredients

Studies suggest that a standardized extract of butterbur (Petasites hybridus) is a powerful migraine-preventive agent. Butterbur has been used for more than 2,000 years for conditions ranging from gastric disorders to allergies. A specialized butterbur root extract has been available in Germany as a prescription remedy since 1988. More than half a million German citizens have used this remarkable plant extract for health concerns such as migraine prevention and allergies. The good news is that this standardized butterbur extract is now also readily available in the United States as a dietary supplement.

Butterbur’s headache-preventive capabilities likely stem from its anti-inflammatory and spasmolytic (muscle-relaxant) effects. It contains active components known as isopetasin, oxopetasin, and petasin, which induce smooth muscle relaxation, particularly in cerebral blood vessel walls. Research indicates that petasin inhibits the proinflammatory lipoxygenase (LOX) enzyme, while both petasin and isopetasin exert highly potent anti-inflammatory effects by inhibiting leukotriene synthesis.

Butterbur extract has also been reported to inhibit cyclooxygenase-2 (COX-2) activity, which relieves pain and inflammation. In addition, butterbur petasins decrease the intracellular concentration of calcium, thus offsetting calcium-induced vasoconstriction, which also helps explain the herb’s anti-inflammatory and spasmolytic effects.

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